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      產品中心

      619基因

      產品中心 > 精準醫療 > 619基因

      619基因


      全面涵蓋:MSK IMPACT和Foundation one CDX中所有基因,檢測34種腫瘤中常見的94種靶向藥基因、66種化療藥基因、35種融合基因及16個免疫檢查點等相關基因變異信息,為腫瘤患者及腫瘤專家提供更全面,更有效的,精準治療方案。

      1、基因檢測可檢測的內容:


      2、基因檢測臨床價值

      全面涵蓋:MSK IMPACT和Foundation one CDX中所有基因,檢測34種腫瘤中常見的94種靶向藥基因、66種化療藥基因、35種融合基因及16個免疫檢查點等相關基因變異信息,為腫瘤患者及腫瘤專家提供更全面,更有效的,精準治療方案。


      3、基因檢測匹配的藥物:

      94個靶向藥基因 匹配96種國內外上市靶向藥
      35個融合基因匹配96種國內外上市靶向藥
      66個化療基因 提供24種化療藥的療效及毒副作用評估
      16個免疫檢查點抑制劑療效評估標記評估免疫檢查點抑制劑敏感性,耐藥性以及風險性
      腫瘤突變負荷 檢測腫瘤突變負荷,評估免疫檢查點抑制劑敏感性


      【96】種國內外上市靶向藥

      NMPA/FDA批準藥物(20種)
      克唑替尼、索拉非尼、曲妥珠單抗、尼妥珠單抗、拉帕替尼、舒尼替尼、依維莫司、硼替佐米達沙替尼、奧希替尼、??颂婺?、塞瑞替尼、貝伐珠單抗尼、瑞戈非尼、尼洛替尼、阿來替尼、帕博西尼、伊馬替尼、吉非替尼、厄洛替尼
      FDA批準藥物(47種)
       魯卡帕尼、瑞博西尼、尼拉帕尼、拉羅替尼、奧拉帕尼、阿法替尼、厄達替尼依西美坦、凡德他尼、阿那曲唑、恩西地平   、侖伐替尼、艾伏尼布、Ado-曲妥珠單抗-美坦新偶聯、氟維司瓊、帕尼單抗 、比尼替尼、恩曲替尼、他莫昔芬、來那替尼、庫潘尼西、帕納替尼、維莫非尼、維莫德吉、依魯替尼、達拉非尼、阿培利西、?,斘髂?、吉列替尼 、魯索替尼 、曲美替尼 、博舒替尼、卡博替尼、康奈非尼、米哚妥林、來曲唑、達克替尼、考比替尼、納武單抗、索尼德吉、帕妥珠單抗、西妥昔單抗、他拉唑帕尼、布吉替尼、勞拉替尼替西羅莫司 、帕博利珠單抗
      臨床II/III期試驗藥物(29種)
      米拉美坦、司美替尼、波齊替尼、BLU-667、Buparlisib、Serabelisib    、GDC-0077、AMG-510     、Asciminib、Tazemetostat、西米普利單抗TK216、Taselisib、BGJ398、      Avapritinib、H3B-8800、卡馬替尼、PLX8394、AZD9496、奎扎替尼       、AZD8186、Debio1347、克倫諾、AZD5363、RO5045337、GSK2636771、替吡法尼、AZD4547、LOXO-292  


      【24】種化療藥物

      阿霉素、奧沙利鉑、表阿霉素、多西他賽、蒽環類、氟尿嘧啶、環磷酰胺、吉西他濱、甲氨蝶呤、卡鉑、卡培他濱、米托蒽醌、喃氟啶、培美曲塞、巰基嘌呤、柔紅霉素、沙利度胺、順鉑、他莫昔芬、亞葉酸、伊立替康、長春瑞濱、長春新堿、紫杉醇       


      4、基因檢測覆蓋的癌種:

      所有的實體瘤——垂體腺瘤、涎腺癌、口腔腫瘤、口咽癌、喉癌、下咽癌、鼻咽癌、甲狀腺癌、神經上皮性腫瘤、鼻腔及鼻竇腫瘤、食管癌、胃癌、腸癌、胃腸間質瘤、胰腺癌、肝癌、膽囊癌、肝外膽管癌、宮頸癌、子宮內膜癌、子宮肉瘤、卵巢癌、腎癌、膀胱癌、前列腺癌、乳腺癌、肺癌、縱隔腫瘤、惡性胸膜間皮瘤、基底細胞癌、鱗狀細胞癌、黑色素瘤、骨腫瘤、軟組織瘤。


      5、619基因檢測覆蓋的基因:

      序號靶向【94】  化療【66】  融合【35】  腫瘤驅動【201】   抑癌【169】   遺傳性腫瘤綜合【134】  免疫相關【16】
      1ABCB1ABCC1ABCC2ABCC5ABCC6ABCG2
      2ABL1ABL2ACVR1ACVR1BADCY2AGO2
      3AKT1AKT2AKT3ALKALOX12BAMER1
      4ANKRD11APCARARAFARFRP1ARID1A
      5ARID1BARID2ARID5BASXL1ASXL2ATM
      6ATP7AATRATRXAURKAAURKBAXIN1
      7AXIN2AXLB2MBABAM1BAP1BARD1
      8BBC3BCL10BCL2BCL2L1BCL2L11BCL2L2
      9BCL6BCORBCORL1BCRBIRC3BLM
      10BMPR1ABRAFBRCA1BRCA2BRD4BRIP1
      11BTG1BTG2BTKC11orf30C8orf34CALR
      12CARD11CARM1CASP7CASP8CBFBCBL
      13CBR3CCND1CCND2CCND3CCNE1CD22
      14CD274CD276CD70CD74CD79ACD79B
      15CDACDC42CDC73CDH1CDK12CDK4
      16CDK6CDK8CDKN1ACDKN1BCDKN2ACDKN2B
      17CDKN2CCEBPACENPACHD2CHD4CHEK1
      18CHEK2CICCMPK1CREBBPCRKLCRLF2
      19CSDE1CSF1RCSF3RCTCFCTLA4CTNNA1
      20CTNNB1CUL3CUL4ACXCR4CYBACYLD
      21CYP17A1CYP19A1CYP1B1CYP2B6CYP2D6CYP3A4
      22CYP4B1CYSLTR2DAXXDCUN1D1DDR1DDR2
      23DHFRDICER1DIS3DNAJB1DNMT1DNMT3A
      24DNMT3BDOT1LDPYDDROSHADSCAMDUSP4
      25DYNC2H1E2F3EEDEGFL7EGFREIF1AX
      26EIF4A2EIF4EELF3EP300EPAS1EPCAM
      27EPHA3EPHA5EPHA7EPHB1EPHB4EPHX1
      28HER2ERBB3ERBB4ERCC1ERCC2ERCC3
      29ERCC4ERCC5ERFERGERRFI1ESR1
      30ETV1ETV4ETV5ETV6EWSR1EZH1
      31EZH2EZRFAM175AFAM46CFAM58AFANCA
      32FANCCFANCD2FANCEFANCFFANCGFANCL
      33FASFAT1FBXW7FGF10FGF12FGF14
      34FGF19FGF23FGF3FGF4FGF6FGFR1
      35FGFR2FGFR3FGFR4FHFLCNFLT1
      36FLT3FLT4FOLR3FOXA1FOXL2FOXO1
      37FOXP1FRS2FUBP1FYNGABRA6GALNT14
      38GATA1GATA2GATA3GATA4GATA6GGH
      39GID4GLI1GNA11GNA13GNAQGNAS
      40GPR124GPS2GREM1GRIN2AGRM3GSK3B
      41GSTA1GSTP1H3F3AH3F3BH3F3CHAS3
      42HDAC1HGFHIST1H1CHIST1H2BDHIST1H3AHIST1H3B
      43HIST1H3CHIST1H3DHIST1H3EHIST1H3FHIST1H3GHIST1H3H
      44HIST1H3IHIST1H3JHIST2H3CHIST2H3DHIST3H3HLA-A
      45HLA-BHNF1AHOXB13HRASHSD3B1HSP90AA1
      46ICOSLGID3IDH1IDH2IFNGR1IGF1
      47IGF1RIGF2IGFBP3IKBKEIKZF1IL10
      48IL7RINHAINHBAINPP4AINPP4BINPPL1
      49INSRIRF2IRF4IRS1IRS2JAK1
      50JAK2JAK3JUNKAT6AKDM5AKDM5C
      51KDM6AKDRKEAP1KELKITKLF4
      52KLHL6KMT2AKMT2BKMT2CKMT2DKNSTRN
      53KRASLATS1LATS2LGR5LMO1LRP1B
      54LRP2LTKLYNLZTR1MAFMAGI2
      55MALT1MAP2K1MAP2K2MAP2K4MAP3K1MAP3K13
      56MAP3K14MAPK1MAPK3MAPKAP1MAXMCL1
      57MDC1MDM2MDM4MED12MEF2BMEN1
      58MERTKMETMGAMITFMKNK1MLH1
      59MPLMRE11AMSH2MSH3MSH6MSI1
      60MSI2MST1MST1RMTAPMTHFRMTOR
      61MTRRMUTYHMYBMYCMYCLMYCN
      62MYD88MYOD1NAT2NBNNCOA3NCOR1
      63NEGR1NF1NF2NFE2L2NFKBIANKX2-1
      64NKX3-1NOS3NOTCH1NOTCH2NOTCH3NOTCH4
      65NPM1NQO1NRASNRG1NSD1NT5C2
      66NTHL1NTRK1NTRK2NTRK3NUDT15NUF2
      67NUP93NUTM1OTOSP2RY8PAK1PAK3
      68PAK7PALB2PARK2PARP1PARP2PARP3
      69PAX5PBRM1PDCD1PDCD1LG2PDGFRAPDGFRB
      70PDK1PDPK1PGRPHOX2BPIK3C2BPIK3C2G
      71PIK3C3PIK3CAPIK3CBPIK3CDPIK3CGPIK3R1
      72PIK3R2PIK3R3PIM1PLCG2PLK2PMAIP1
      73PMS1PMS2PNRC1POLD1POLEPPARG
      74PPM1DPPP2R1APPP2R2APPP4R2PPP6CPRDM1
      75PRDM14PREX2PRKAR1APRKCIPRKD1PRKDC
      76PRSS8PTCH1PTENPTP4A1PTPN11PTPRD
      77PTPROPTPRSPTPRTQKIRAB35RAC1
      78RAC2RAD21RAD50RAD51RAD51BRAD51C
      79RAD51DRAD52RAD54LRAF1RANBP2RARA
      80RASA1RB1RBM10RECQLRECQL4REL
      81RETRFWD2RHEBRHOARICTORRIT1
      82RNF43ROS1RPS6KA4RPS6KB2RPTORRRAGC
      83RRASRRAS2RRM1RSPO2RTEL1RUNX1
      84RUNX1T1RXRARYBPSDC4SDHASDHAF2
      85SDHBSDHCSDHDSEMA3CSESN1SESN2
      86SESN3SETD2SETD8SF3B1SGK1SH2B3
      87SH2D1ASHOC2SHQ1SLC19A1SLC22A16SLC22A2
      88SLC28A2SLC29A1SLC34A2SLCO1B1SLCO1B3SLIT2
      89SLX4SMAD2SMAD3SMAD4SMARCA4SMARCB1
      90SMARCD1SMOSMYD3SNCAIPSOCS1SOD2
      91SOS1SOX10SOX17SOX2SOX9SPEN
      92SPG7SPOPSPRED1SPTA1SRCSRSF2
      93STAG2STAT3STAT4STAT5ASTAT5BSTK11
      94STK19STK40SUFUSULT1C4SUZ12SYK
      95TAF1TAP1TAP2TBX3TCEB1TCF3
      96TCF7L2TEKTERCTERTTET1TET2
      97TGFBR1TGFBR2TIPARPTMEM127TMPRSS2TNFAIP3
      98TNFRSF14TOP1TOP2ATP53TP53BP1TP63
      99TRAF2TRAF7TSC1TSC2TSHRTYMS
      100TYRO3U2AF1UGT1A1UMPSUPF1VEGFA
      101VHLVTCN1WHSC1WHSC1L1WISP3WT1
      102WWTR1XIAPXPCXPO1XRCC1XRCC2
      103YAP1YES1ZBTB2ZFHX3ZNF217ZNF423
      104ZNF703     
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